AlergiaPT: A Portuguese media campaign to inspire people with allergies to make a positive change in their life.

Allergic diseases comprise a significant cause of morbidity worldwide and a substantial burden on the health and medical systems of both developed and emerging economies. Although highly prevalent, relatively severe, and largely impactful on the quality of life of patients, allergic diseases are commonly trivialized. Increasing awareness of the relevance of allergic diseases as a major public health problem might lead to an improved acknowledgment by governments and health authorities. Based on the positive impact that media campaigns might have on health-related behaviors, as well as the large use of social media by different types of users, social media might be used as a powerful tool for spreading awareness and education even more effective than traditional face-to-face communication. Therefore, we aimed to develop a social media-based communication program, the AlergiaPT, reaching all stakeholders, to increase the awareness of allergic diseases tackling the causes, prevention, control, and economic impact. The AlergiaPT will provide user-generated and interactive content toward engagement, include both long-form and short-form video productions toward education, as well as stories and time-sensitive content toward empowerment. It will be targeted to all populations, engaging different stakeholders. Contents will address the 5 campaign goals: i) allergy health is promoted; ii) tolerance is actively reinforced, and avoidance reduced; iii) treatment control and guided self-management of patients of asthma, rhinitis, food allergy, and atopic eczema are strengthened; iv) recognition and treatment of severe allergy and anaphylaxis are improved, and v) indoor air quality is promoted. Engagement on the campaign will be promoted through stepwise educational takeaways meetings using different social media, and targeting all audience groups, by promoting the organization of resources for common goals and the involvement of social media to improve public awareness. The impact of AlergiaPT will be assessed through google analytics.

A blueprint of septin expression in human tissues.

Septins are GTP-binding proteins that polymerize to form filaments involved in several important biological processes. In human, 13 distinct septins genes are classified in four groups. Filaments formed by septins are complex and usually involve members of each group in specific positions. Expression data from GTEx database, a publicly available expression database with thousands of samples derived from multiple human tissues, was used to evaluate the expression of septins. The brain is noticeably a hotspot for septin expression where few genes contribute to a large portion of septin transcript pool. Co-expression data between septins suggests two predominant specific complexes in brain tissues and one filament in other tissues. SEPT3 and SEPT5 are two genes highly expressed in the brain and with a strong co-expression in all brain tissues. Additional analysis shows that the expression of these two genes is highly variable between individuals, but significantly dependent on the individual's age. Age-dependent decrease of expression from those two septins involved in synapses reinforces their possible link with cognitive decay and neurodegenerative diseases associated with aging. Analysis of enrichment of Gene Ontology terms from lists of genes consistently co-expressed with septins suggests participation in diverse biological processes, pointing out some novel roles for septins. Interestingly, we observed strong consistency of some of these terms with experimentally described roles of septins. Coordination of septins expression with genes involved in DNA repair and cell cycle control may provide insights for previously described links between septins and cancer.

A interceptação precoce da mordida cruzada posterior e mordida aberta anterior: uma alternativa viável / The early interception of the posterior crossibite and anterior open bite: feasible alternative

Este trabalho tem como objetivo elucidar algumas dúvidas e questionamentos sobre o tratamento ortordôntico preventivo e interceptador, sua época de atuação, assim como quais as más oclusões que podem, devem e as que não devem ser tratadas precocemente pelo profissional. Ressalta também a importância do tratamento precoce da mordida cruzada posterior e da mordida aberta anterior, apresentando dois casos clínicos, tratados com aparelhos removíveis e acompanhados até a correção da forma dos arcos dentários e suas funções adequadas

Significado da invaginaçäo gengival em locais de extraçäo dentária após o fechamento ortodôntico dos espaços / Significance of gingival invagination in tooth extraction sites after orthodontic space closure

A invaginaçäo ou fenda gengival é uma cicatriz decorrente do tratamento ortodôntico localizada na papila gengival especialmente, e näo exclusivamente, em locais de extraçäo dentária. Objetivou-se, inicialmente, rever o comportamento gengival decorrente da movimentaçäo dentária induzida, discutir os prováveis mecanismos formadores da invaginaçäo gengival, bem como expressar o seu significado clínico e microscópico. Verificou-se que as invaginaçöes gengivais säo altamente prevalentes (95 por cento a 100 por cento) em locais de extraçäo dentária após o fechamento ortodôntico dos espaços e, embora nem sempre se autocorrijam, sua frequência diminui. Fatores como a largura da mucosa ceratinizada, a inclinaçäo de dentes adjacentes, ou a saúde gengival näo influenciam a formaçäo e a severidade da invaginaçäo gengival. Microscopicamente, o quadro denota a presença de um sulco com hiperplasia epitelial e um tecido conjuntivo desorganizado, caracterizado pela perda de colágeno, contrastando com o aumento da síntese de glicosaminoglicanas. Apesar das controvérsias, admite-se, tembém, näo serem responsáveis pela reabertura de espaços na regiäo da extraçäo dentária. Portanto, conclui-se que a invaginaçäo gengival näo tem impacto clínico apreciável e conhecido durante e após o tratamento ortodôntico. A cirurgia gengival com a finalidade de eliminar a invaginaçäo gengival näo se justifica, caso näo esteja associada à hiperplasia gengival persistente ou ao comprometimento estético do contorno gengival